4/16 @ Columbus Crew, 7:30 p.m. ESPN+
The Lions lone road match in April is against the 2020 MLS Cup Champions at their new home Lower.com Field for just the second time ever. Last season was a massive disappointment for Caleb Porter's team, especially after the Crew was touted as a potential Shield and Champions League contender in the preseason. Orlando and Columbus played a pair of exciting matches last season, each a 3-2 win for the home team.